For research use only. Products are supplied strictly for laboratory and research purposes and are not intended for human consumption.
- Batch tested
- COA available
- Research use only
Metabolic research
MOTS-c
Mitochondrial-derived 16-amino-acid peptide studied in cellular energy metabolism and AMPK signalling models.
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Verified test results
Every batch, independently documented.
Review the testing information and certificate available for the selected product batch.
ILS Laboratories
Certificate of Analysis
99.61%
Purity
- Lot
- APMOTS01
- Tested
- 12 Jun 2026
- Label claim
- 10mg vial
- Measured
- 10mg vial
Full QC panel
8 results reported
Appearance
Visual
White lyophilised cake
PassPurity
HPLC-UV, 214nm
99.61%
PassNet peptide content
Nitrogen determination
Conforms
PassIdentity
LC-MS (ESI+)
Confirmed
PassBacterial endotoxin
LAL kinetic chromogenic
< 0.05 EU/mg
PassHeavy metals
ICP-MS
Not detected
PassSterility
USP <71>
No growth
PassResidual solvents
GC headspace
Within limits
Pass
Every batch on record
View available certificates for previous product lots.
Product information
Research Detail
Research-grade MOTS-c peptide. A mitochondrial-derived 16-amino acid peptide supplied as lyophilized powder for in vitro research. Third-party tested with Certificate of Analysis available.
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino acid mitochondrial-derived peptide studied for its role in metabolic signalling, cellular energy regulation, mitochondrial communication, and adaptive stress-response pathways.
Unlike peptides encoded by nuclear DNA, MOTS-c is encoded within the mitochondrial genome. In laboratory research, it is examined for its relationship with AMPK activation, glucose metabolism, insulin-signalling models, nuclear gene regulation, and stress-adaptation pathways.
Because of its connection to mitochondrial signalling and metabolic resilience, MOTS-c is a major research compound in studies of energy balance, cellular stress response, exercise biology, ageing models, and systemic metabolic regulation.
Compound Profile
- Peptide Type
- Mitochondrial-derived peptide
- Sequence
- MRWQEMGYIFYPRKLR
- Molecular Weight
- 2,174.6 g/mol
- Molecular Formula
- C101H152N28O22S2
- CAS Number
- 1627580-64-6
- PubChem CID
- 155885767
- Research Category
- Metabolic signalling & mitochondrial communication
- Purity
- ≥99% (HPLC verified)
Key Areas of Investigation
MOTS-c has been studied across metabolic, mitochondrial, cellular, muscular, and systemic research models. Published research discusses its role in AMPK activation, glucose metabolism, and mitochondrial-nuclear communication.
These findings support MOTS-c as a valuable research compound for studying mitochondrial signalling and metabolic adaptation, but they do not establish approved therapeutic use.
- Metabolic Research: Glucose utilisation, insulin-signalling models, AMPK activation, lipid metabolism, and energy-balance pathways.
- Mitochondrial Research: Mitochondrial communication, mitochondrial-derived peptide signalling, energy sensing, and mitochondrial-nuclear interaction.
- Cellular Research: Adaptive stress response, nuclear gene regulation, oxidative-stress models, cell survival signalling, and metabolic resilience.
- Muscle Research: Skeletal-muscle metabolism, exercise-response pathways, muscle homeostasis, and age-related muscle-function research.
- Systemic Research: Metabolic flexibility, inflammatory-response pathways, ageing biology, and physiological resilience.
Scientific references
- Lee C. et al. (2015)
- Lee C., Yen K., Cohen P. (2016)
- Kim K.H. et al. (2018)
- Reynolds J.C. et al. (2021)
- Yang B. et al. (2021)
- Wan W. et al. (2023)
- Kong B.S. et al. (2023)
- Zheng Y. et al. (2023)
Technical specifications
Compound Information
Molecular profile
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, commonly used in metabolic and cellular energy research models. Each vial ships with lot-matched HPLC and mass spectrometry data.
- Chemical class
- Mitochondrial-derived peptide
- CAS number
- 1627580-64-6
- Molecular weight
- 2174.6 g/mol
- Amino acids
- 16
- Formula
- C101H152N28O22S2
- Sequence
- MRWQEMGYIFYPRKLR
Storage requirements
Stability information
- −20°C
Lyophilised powder
Sealed, protected from light. Stable 24 months.
- 2–8°C
Reconstituted
Use within 28 days of reconstitution.
- Ambient
In transit
Store sealed at 2–8°C, protected from light
Store sealed at 2–8°C, protected from light
Important research notice
Not for human, veterinary, or food use.
These products are supplied exclusively for laboratory and research purposes and are not intended for human consumption, diagnosis, treatment, cure, or prevention of disease.
Product information and research references are provided for educational and laboratory reference purposes.