For research use only. Products are supplied strictly for laboratory and research purposes and are not intended for human consumption.
- Batch tested
- COA available
- Research use only
Triple agonist
Retatrutide
Triple receptor agonist sequence referenced in GIP, GLP-1 and glucagon receptor research across metabolic models.
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Verified test results
Every batch, independently documented.
Review the testing information and certificate available for the selected product batch.
ILS Laboratories
Certificate of Analysis
99.61%
Purity
- Lot
- APRETA02
- Tested
- 12 Jun 2026
- Label claim
- 10mg vial
- Measured
- 10mg vial
Full QC panel
8 results reported
Appearance
Visual
White lyophilised cake
PassPurity
HPLC-UV, 214nm
99.61%
PassNet peptide content
Nitrogen determination
Conforms
PassIdentity
LC-MS (ESI+)
Confirmed
PassBacterial endotoxin
LAL kinetic chromogenic
< 0.05 EU/mg
PassHeavy metals
ICP-MS
Not detected
PassSterility
USP <71>
No growth
PassResidual solvents
GC headspace
Within limits
Pass
Every batch on record
View available certificates for previous product lots.
Product information
Research Detail
Research-grade Retatrutide peptide. A triple GLP-1/GIP/glucagon receptor agonist supplied as lyophilized powder for in vitro research. Third-party tested with Certificate of Analysis available.
What is Retatrutide?
Retatrutide (LY3437943) is an investigational triple-receptor agonist studied for its interaction with three major metabolic hormone receptors: GLP-1, GIP, and glucagon. Unlike single-pathway peptide compounds, retatrutide is designed to engage multiple metabolic signalling systems simultaneously.
In laboratory, preclinical, and controlled clinical research settings, it is examined for its relationship with glucose regulation, insulin-signalling pathways, lipid metabolism, energy balance, endocrine communication, and integrated metabolic control.
Because it targets GLP-1, GIP, and glucagon receptor pathways together, retatrutide is of strong interest in research models focused on metabolic regulation, body-composition signalling, hepatic lipid biology, insulin sensitivity, and systemic energy balance.
Compound Profile
- Common Research Name
- Retatrutide
- Development Name
- LY3437943
- Molecular Weight
- ~4,731 g/mol
- Molecular Formula
- C221H342N46O68
- CAS Number
- 2381089-83-2
- PubChem CID
- 171390338
- Peptide Type
- Synthetic triple GLP-1/GIP/glucagon receptor agonist
- Purity
- ≥99% (HPLC verified)
Key Areas of Investigation
Retatrutide has been studied across metabolic, endocrine, hepatic, cardiovascular, and systemic research models. The main research interest centres on its ability to activate three hormone receptor pathways that are closely involved in metabolic regulation.
These findings support retatrutide as a valuable research compound for studying integrated metabolic regulation, but they do not establish approved therapeutic use.
- Metabolic Research: Glucose regulation, insulin sensitivity models, nutrient utilisation, and energy-balance signalling.
- Endocrine Research: GLP-1, GIP, and glucagon receptor activity, incretin biology, and multi-hormone communication.
- Hepatic Research: Liver-fat models, hepatic lipid metabolism, and glucagon-related energy pathways.
- Body-Composition Research: Adipose-tissue signalling, appetite-related pathways, and lean/fat mass research.
- Cardiometabolic Research: Lipid metabolism, cholesterol dynamics, inflammatory-response pathways, and systemic metabolic resilience.
Scientific references
- Coskun T. et al. (2022)
- Urva S. et al. (2022)
- Jastreboff A.M. et al. (2023)
- Rosenstock J. et al. (2023)
- Sanyal A.J. et al. (2024)
- Katsi V. et al. (2025)
Technical specifications
Compound Information
Molecular profile
What is Retatrutide?
Retatrutide is a triple-agonist peptide sequence referenced in GIP, GLP-1 and glucagon receptor research. Available in three vial strengths so protocols can be matched without waste.
- Chemical class
- Synthetic peptide analogue
- CAS number
- 2381089-83-1
- Molecular weight
- 4731.3 g/mol
- Amino acids
- 39
- Targets
- GIPR / GLP-1R / GCGR
Storage requirements
Stability information
- −20°C
Lyophilised powder
Sealed, protected from light. Stable 24 months.
- 2–8°C
Reconstituted
Use within 28 days of reconstitution.
- Ambient
In transit
Store sealed at 2–8°C, protected from light
Store sealed at 2–8°C, protected from light
Important research notice
Not for human, veterinary, or food use.
These products are supplied exclusively for laboratory and research purposes and are not intended for human consumption, diagnosis, treatment, cure, or prevention of disease.
Product information and research references are provided for educational and laboratory reference purposes.